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NEUMED PRODUCT INTRODUCTION
PRODUCTS
PRODUCT OVERVIEW

HOVENIA DULCIS FRUIT STALK EXTRACT POWDER [HT426]

AN MFDS-RECOGNIZED FUNCTIONAL INGREDIENT THAT MAY HELP PROTECT THE LIVER FROM ALCOHOL-INDUCED DAMAGE

MFDS Recognition No. 2014-1

A NATURAL LIVER HEALTH INGREDIENT THAT BEGINS WITH RAW MATERIAL SELECTION

HT426 is a standardized natural product ingredient developed from Hovenia dulcis fruit stalk. It has been recognized by the MFDS for the functionality of “may help protect the liver from alcohol-induced damage.” NeuMed has studied liver health not simply as a matter of hangover relief, but from the perspective of protecting the liver from alcohol-induced damage. HT426 was evaluated for both liver-health-related and safety-related indicators in a 12-week human study involving 57 adults. Developed through on-site production-region reviews and raw material selection based on pharmacognosy standards by researchers from Kyung Hee University College of Korean Medicine, HT426 is a B2B functional ingredient available to brands developing liver health products.

WHAT MAKES HT426 SPECIAL
FEATURES

A Dual Protective Approach: Alcohol Metabolism Support and Antioxidant Defense

IN 12 WEEKS

γ-GTP Improvement

A significant decrease in γ-GTP,
a key indicator related to alcohol-induced
liver damage, was observed in a human study.

LIVER DAMAGE INDICATORS

Up to 87.5% Improvement

Improvement in liver damage indicators
such as AST and ALT was observed in
a chronic alcohol intake model.

DUAL PROTECTION

Alcohol Metabolism Support
· Antioxidant Defense

HT426 has been studied for its dual approach
to supporting alcohol metabolism and helping
 protect liver cells from reactive oxygen species.

57 Participants

12 Weeks

2,460mg

2014

mobile background
PROBLEMS IN LIVER HEALTH
PROBLEM

The liver is often called a silent organ. By the time symptoms are felt, damage may already be progressing.

Alcohol consumption is linked to millions of deaths worldwide each year. Repeated alcohol exposure can place a burden on the liver through oxidative stress, fat accumulation, and inflammatory responses, often before clear symptoms appear. Health checkup markers such as γ-GTP, AST, and ALT may already be sending warning signals. Liver health requires more than hangover relief; it requires support for protecting liver cells from alcohol-induced damage.

PROBLEM. 01

2.6 MILLION DEATHS
ANNUALLY


Alcohol-Related
Deaths Worldwide

Alcohol remains
a major global health burden

PROBLEM. 02

REPEATED ALCOHOL
 EXPOSURE


Oxidative Stress
and Liver Burden

Alcohol metabolism can increase oxidative stress and place stress on liver cells

PROBLEM. 03

THE SILENT ORGAN


Progression Without
Noticeable Symptoms

Rising γ-GTP, AST, and
ALT may signal liver stress

HT426 DEVELOPMENT STORY
STORY

Liver health research began with one principle
“The quality of the raw material defines the reliability of the ingredient.”

2011
BEGINNING OF LIVER HEALTH
INGREDIENT RESEARCH

Researchers at Kyung Hee University focused on the potential of Hovenia dulcis fruit stalk, which has been traditionally used in relation to alcohol-related liver burden. Through on-site production-region reviews and pharmacognosy-based evaluation, they selected raw materials suitable for liver health ingredient development.


2014
MFDS
RECOGNITION

HT426 was evaluated for liver-health-related functionality and safety through animal and human studies. In 2014, it was recognized by the MFDS for the functionality of helping protect the liver from alcohol-induced damage.


PRESENT
EXPANSION AS
A LIVER HEALTH INGREDIENT

HT426 has been applied to various liver health products in collaboration with health functional food brands. Based on stable raw material supply and human study data, NeuMed supports the development of differentiated liver health products.


SUPPORTING LIVER HEALTH AGAINST ALCOHOL-INDUCED DAMAGE
HOW IT WORKS

HT426’s Dual Approach: Alcohol Metabolism Support and Antioxidant Defense

As alcohol is metabolized in the liver, it can produce acetaldehyde and reactive oxygen species, placing stress on liver cells. HT426 has been studied for its potential to support liver health by helping reduce the burden of alcohol metabolism and oxidative stress.

STEP. 01

ALCOHOL
METABOLISM SUPPORT


Reducing Toxic
Metabolite Burden

Alcohol is broken down in the liver and can produce toxic metabolites such as acetaldehyde. HT426 has been studied in relation to reducing the burden placed on liver cells during alcohol metabolism.

STEP. 02

ANTIOXIDANT
DEFENSE


Reduci
Oxidative Stress

HT426 has been studied in relation to reducing reactive oxygen species and oxidative stress that may increase with alcohol intake.

STEP. 03

LIVER
HEALTH SUPPORT


Supporting Liver-Health
-Related Indicators

Through alcohol metabolism support and antioxidant defense, HT426 may help support liver-health-related indicators associated with alcohol-induced damage.

γ-GTP 47% Decrease

Observed in a chronic alcohol intake model


AST 85% Decrease

Observed in a chronic alcohol intake model


ALT 88% Decrease

Observed in a chronic alcohol intake model


mobile background
EVIDENCE
HUMAN
CLINICAL TRIALS

Evaluated for liver-health-related indicators in a 12-week human study

In a 12-week randomized, placebo-controlled human study involving 57 adults aged 20–70, the group taking HT426 2,460 mg/day showed meaningful changes in liver-health-related indicators.

PRIMARY INDICATOR
· γ-GTP

APPROXIMATELY 28 U/L DECREASE


Reduction in a key
liver health indicator

After 12 weeks of intake, γ-GTP, a key indicator related to alcohol-induced liver damage, decreased compared with the placebo group.

SECONDARY INDICATOR
· TRIGLYCERIDES

SIGNIFICANT
DECREASE


Reduction in blood
triglyceride levels

Blood triglyceride levels decreased compared with baseline after 12 weeks of intake.

 WHO IS HT426 FOR?
BENEFITS

For consumers concerned about liver health and brands seeking a science-backed liver health ingredient

HT426 is an MFDS-recognized functional ingredient for liver health, developed for those seeking support against alcohol-induced liver damage. Human and animal studies have evaluated its effects on liver-health-related indicators and alcohol-induced liver burden.

CONSUMERS

FOR CONSUMERS CONCERNED
ABOUT LIVER HEALTH 


Liver Health Indicator Support

In a 12-week human study, γ-GTP, a key indicator related to alcohol-induced liver damage, showed improvement.

Support Against Alcohol-Induced Liver Burden

HT426 has been studied in acute and chronic alcohol intake models for its potential to help protect liver cells from alcohol-induced damage.

Liver Health Management
After Drinking

HT426 may help support liver health by helping protect the liver from alcohol-induced damage.

Traditional Botanical
Background

Hovenia dulcis fruit stalk has traditionally been used in relation to alcohol-related liver burden.

B2B PARTNERS AND BRANDS

FOR BRANDS SEEKING A DIFFERENTIATED LIVER HEALTH INGREDIENT


Pharmacognosy-Based Raw Material Selection

NeuMed selected Hovenia dulcis fruit stalk raw materials through production-region review and pharmacognosy-based evaluation with researchers from Kyung Hee University College of Korean Medicine.

Human and Animal Study Data

NeuMed has secured human study data as well as data from acute and chronic alcohol-induced liver damage models and toxicant-induced liver damage models.

MFDS-Recognized Functionality

In 2014, HT426 was recognized by the MFDS for the functionality of helping protect the liver from alcohol-induced damage.

Raw Material Supply and Quality Management

NeuMed manages ingredient consistency through a quality management system that includes manufacturer analysis, in-house analysis, and third-party accredited laboratory analysis.

HT426 RAW MATERIALS
HT426 BOTANICAL INGREDIENTS

Hovenia dulcis Fruit Stalk Selected Through Pharmacognosy-Based Evaluation

Even with the same Hovenia dulcis fruit stalk, ingredient quality can vary depending on the production region and raw material standards. Through on-site production-region reviews and pharmacognosy-based evaluation, NeuMed selects Hovenia dulcis fruit stalk and manages the quality consistency of HT426 through scientific validation.

ALCOHOL METABOLISM SUPPORT · LIVER HEALTH SUPPORT

HOVENIA DULCIS FRUIT STALK


Traditional Records

Hovenia dulcis fruit stalk has long been used in traditional medicine in relation to alcohol-related discomfort and liver burden. Traditional records associate Hovenia dulcis with helping the body recover after alcohol consumption.

Modern Research

Components derived from Hovenia dulcis fruit stalk have been studied in relation to liver-health-related pathways, including alcohol metabolism, antioxidant defense, and lipid metabolism regulation. In alcohol exposure models, studies have also reported potential effects related to gut microbiota balance and liver fatty acid metabolism.

RESEARCH · RAW MATERIALS · QUALITY
SCIENTIFIC RELIABILITY

HT426’s reliability supported by research validation, raw material selection, and quality management

NeuMed selects raw materials based on pharmacognosy standards and manages HT426’s consistency through modern research and a structured quality management system.

RESEARCH VALIDATION

HUMAN AND
ANIMAL STUDIES


HT426 has been evaluated in a human study and in acute and chronic alcohol-induced liver damage models, with changes observed in liver-health-related indicators.

mobile background
INGREDIENT SUPPLY INQUIRIES
CONTACT

Start a new liver health product with HT426, a functional ingredient developed through pharmacognosy-based raw material selection. HT426 can be supplied as a standardized functional ingredient for brands developing liver health products in various formats, including tablets, capsules, gummies, powders, and food applications. 

Based on human study data, animal model data, and a three-step quality management system, NeuMed supports partner brands seeking a differentiated liver health ingredient.

PRODUCT OVERVIEW

HOVENIA DULCIS FRUIT STALK EXTRACT POWDER [HT426]

AN MFDS-RECOGNIZED FUNCTIONAL INGREDIENT THAT MAY HELP PROTECT THE LIVER FROM ALCOHOL-INDUCED DAMAGE

MFDS Recognition No. 2014-1

A NATURAL LIVER HEALTH INGREDIENT THAT BEGINS WITH RAW MATERIAL SELECTION

HT426 is a standardized natural product ingredient developed from Hovenia dulcis fruit stalk. It has been recognized by the MFDS for the functionality of “may help protect the liver from alcohol-induced damage.” NeuMed has studied liver health not simply as a matter of hangover relief, but from the perspective of protecting the liver from alcohol-induced damage.

HT426 was evaluated for both liver-health-related and safety-related indicators in a 12-week human study involving 57 adults.

Developed through on-site production-region reviews and raw material selection based on pharmacognosy standards by researchers from Kyung Hee University College of Korean Medicine, HT426 is a B2B functional ingredient available to brands developing liver health products.

WHAT MAKES HT426 SPECIAL
FEATURES

A Dual Protective Approach: Alcohol Metabolism Support and Antioxidant Defense

IN
12 WEEKS

γ-GTP
Improvement

A significant decrease in γ-GTP,
a key indicator related to alcohol-induced
liver damage, was observed in a human study.

LIVER DAMAGE INDICATORS

Up to 87.5%
Improvement

Improvement in liver damage indicators
such as AST and ALT was observed in
a chronic alcohol intake model.

DUAL
PROTECTION

Alcohol Metabolism Support
 · Antioxidant Defense

HT426 has been studied for its dual approach
to supporting alcohol metabolism and helping
protect liver cells from reactive oxygen species.

57
Participants

12
Weeks

2,460
mg

2014

mobile background
PROBLEMS IN LIVER HEALTH
PROBLEM

The liver is often called a silent organ.
By the time symptoms are felt, damage may already be progressing.

Alcohol consumption is linked to millions of deaths worldwide each year.
Repeated alcohol exposure can place a burden on the liver through oxidative stress,
fat accumulation, and inflammatory responses, often before clear symptoms appear.

Health checkup markers such as γ-GTP, AST, and ALT may already be sending warning signals.
Liver health requires more than hangover relief; it requires support for protecting liver cells from alcohol-induced damage.

PROBLEM. 01

2.6 MILLION DEATHS ANNUALLY


Alcohol-Related
Deaths Worldwide

Alcohol remains
a major global health burden

PROBLEM. 02

REPEATED ALCOHOL
EXPOSURE


Oxidative Stress
and Liver Burden

Alcohol metabolism can increase oxidative
stress and place stress on liver cells

PROBLEM. 03

THE SILENT
ORGAN


Progression Without
Noticeable Symptoms

Rising γ-GTP, AST, and
ALT may signal liver stress

HT426 DEVELOPMENT STORY
STORY

Liver health research began with one principle
“The quality of the raw material defines the reliability of the ingredient.”

2011
BEGINNING OF LIVER HEALTH
INGREDIENT RESEARCH

Researchers at Kyung Hee University focused on the potential of Hovenia dulcis fruit stalk, which has been traditionally used in relation to alcohol-related liver burden. Through on-site production-region reviews and pharmacognosy-based evaluation, they selected raw materials suitable for liver health ingredient development.


2014
MFDS
RECOGNITION

HT426 was evaluated for liver-health-related functionality and safety through animal and human studies. In 2014, it was recognized by the MFDS for the functionality of helping protect the liver from alcohol-induced damage.


PRESENT
EXPANSION AS
A LIVER HEALTH INGREDIENT

HT426 has been applied to various liver health products in collaboration with health functional food brands. Based on stable raw material supply and human study data, NeuMed supports the development of differentiated liver health products.


SUPPORTING LIVER HEALTH AGAINST ALCOHOL-INDUCED DAMAGE
HOW IT WORKS

HT426’s Dual Approach: Alcohol Metabolism Support and Antioxidant Defense

As alcohol is metabolized in the liver, it can produce acetaldehyde and reactive oxygen species, placing stress on liver cells.

HT426 has been studied for its potential to support liver health by helping reduce the burden of alcohol metabolism and oxidative stress.

STEP. 01

ALCOHOL
METABOLISM
SUPPORT


Reducing Toxic
Metabolite Burden

Alcohol is broken down in the liver and can produce toxic metabolites such as acetaldehyde. HT426 has been studied in relation to reducing the burden placed on liver cells during alcohol metabolism.

STEP. 02

ANTIOXIDANT
DEFENSE
.


Reducing
Oxidative Stress

HT426 has been studied in relation to reducing reactive oxygen species and oxidative stress that may increase with alcohol intake.

STEP. 03

LIVER
HEALTH SUPPORT
.


Supporting Liver-Health
-Related Indicators

Through alcohol metabolism support and antioxidant defense, HT426 may help support liver-health-related indicators associated with alcohol-induced damage.

γ-GTP 47%
Decrease

Observed in a chronic alcohol intake model


AST 85%
Decrease

Observed in a chronic alcohol intake model


ALT 88%
Decrease

Observed in a chronic alcohol intake model


mobile background
EVIDENCE
HUMAN CLINICAL TRIALS

Evaluated for liver-health-related indicators in a 12-week human study

In a 12-week randomized, placebo-controlled human study involving 57 adults aged 20–70,
the group taking HT426 2,460 mg/day showed meaningful changes in liver-health-related indicators.

PRIMARY INDICATOR · γ-GTP

APPROXIMATELY
28 U/L DECREASE


Reduction in a key
liver health indicator

After 12 weeks of intake, γ-GTP, a key indicator related to alcohol-induced
liver damage, decreased compared with the placebo group.

SECONDARY INDICATOR · TRIGLYCERIDES

SIGNIFICANT
DECREASE


Reduction in blood
triglyceride levels

Blood triglyceride levels decreased compared
with baseline after 12 weeks of intake.

WHO IS HT426 FOR?
BENEFITS

For consumers concerned about liver health
and brands seeking a science-backed liver health ingredient

HT426 is an MFDS-recognized functional ingredient for liver health,
developed for those seeking support against alcohol-induced liver damage.
Human and animal studies have evaluated its effects
on liver-health-related indicators and alcohol-induced liver burden.

CONSUMERS

FOR CONSUMERS
CONCERNED
ABOUT LIVER HEALTH 

Liver Health Indicator Support

In a 12-week human study, γ-GTP,
a key indicator related to alcohol-induced
liver damage, showed improvement.

Support Against Alcohol-Induced Liver Burden

HT426 has been studied in acute and chronic alcohol intake models for
its potential to help protect liver cells from alcohol-induced damage.

Liver Health Management After Drinking

HT426 may help support liver health by helping protect
the liver from alcohol-induced damage.

Traditional Botanical Background

Hovenia dulcis fruit stalk
has traditionally been used
in relation to alcohol-related liver burden.

B2B PARTNERS AND BRANDS

FOR BRANDS SEEKING
A DIFFERENTIATED
LIVER HEALTH INGREDIENT

Pharmacognosy-Based Raw Material Selection

NeuMed selected Hovenia dulcis fruit stalk raw materials through
production-region review and pharmacognosy-based evaluation
with researchers from Kyung Hee University College of Korean Medicine.

Human and Animal Study Data

NeuMed has secured human study data as well as data from acute and chronic
alcohol-induced liver damage models and toxicant-induced liver damage models.

MFDS-Recognized Functionality

In 2014, HT426 was recognized by the MFDS for the functionality
of helping protect the liver from alcohol-induced damage.

Raw Material Supply and Quality Management

NeuMed manages ingredient consistency through a quality management system
that includes manufacturer analysis, in-house analysis, and third-party accredited
laboratory analysis.

HT426 RAW MATERIALS
HT426 BOTANICAL INGREDIENTS

Hovenia dulcis Fruit Stalk Selected Through Pharmacognosy-Based Evaluation

Even with the same Hovenia dulcis fruit stalk, ingredient quality can vary depending on the production region and raw material standards. Through on-site production-region reviews and pharmacognosy-based evaluation, NeuMed selects Hovenia dulcis fruit stalk and manages the quality consistency of HT426 through scientific validation.

ALCOHOL METABOLISM SUPPORT · LIVER HEALTH SUPPORT

HOVENIA DULCIS FRUIT STALK


Traditional Records

Hovenia dulcis fruit stalk has long been used in traditional medicine in relation to alcohol-related discomfort and liver burden. Traditional records associate Hovenia dulcis with helping the body recover after alcohol consumption.

Modern Research

Components derived from Hovenia dulcis fruit stalk have been studied in relation to liver-health-related pathways, including alcohol metabolism, antioxidant defense, and lipid metabolism regulation. In alcohol exposure models, studies have also reported potential effects related to gut microbiota balance and liver fatty acid metabolism.

RESEARCH · RAW MATERIALS · QUALITY
SCIENTIFIC RELIABILITY

HT426’s reliability supported by research validation, raw material selection, and quality management

NeuMed selects raw materials based on pharmacognosy standards
and manages HT426’s consistency through modern research and a structured quality management system.

RESEARCH VALIDATION

HUMAN AND
ANIMAL STUDIES


HT426 has been evaluated in a human study and in acute and chronic alcohol-induced liver damage models, with changes observed in liver-health-related indicators.

RAW MATERIAL MANAGEMENT

PHARMACOGNOSY
-BASED SELECTION


Hovenia dulcis fruit stalk raw materials are selected through production-region review and pharmacognosy-based evaluation.

QUALITY MANAGEMENT

THREE-STEP QUALITY
CONTROL SYSTEM


Manufacturer analysis, NeuMed in-house analysis, and third-party accredited laboratory analysis are conducted to help verify ingredient quality, purity, and stability.

mobile background
INGREDIENT SUPPLY INQUIRIES
CONTACT

Start a new liver health product with HT426, a functional ingredient developed through pharmacognosy-based raw material selection. HT426 can be supplied as a standardized functional ingredient for brands developing liver health products in various formats, including tablets, capsules, gummies, powders, and food applications. 

Based on human study data, animal model data,
and a three-step quality management system,
NeuMed supports partner brands seeking a differentiated liver health ingredient.

COMPANY : NEUMED, Inc / CEO : Hocheol Kim 
TEL : +82-2-564-9140 / FAX : +82-2-564-9290
MAIL : sales@neumed.co.kr / BUSINESS LICENSE : 204-81-77134
ADD : 6F, 88 Imun-ro, Dongdaemun-gu, Seoul, Republic of Korea

4F, Seongsu SK V1 CENTER I, 48 Achasan-ro 17-gil, Seongdong-gu, Seoul, Republic of Korea

ⓒ 2026 NEUMED. ALL RIGHTS RESERVED.

COMPANY : NEUMED, Inc / CEO : Hocheol Kim 
TEL : +82-2-564-9140 / FAX : +82-2-564-9290
MAIL : sales@neumed.co.kr
BUSINESS LICENSE : 204-81-77134
ADD : 6F, 88 Imun-ro, Dongdaemun-gu,
Seoul, Republic of Korea

4F, Seongsu SK V1 CENTER I, 48 Achasan-ro
17-gil, Seongdong-gu, Seoul, Republic of Korea 

ⓒ 2026 NEUMED. ALL RIGHTS RESERVED.