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NEUMED PRODUCT INTRODUCTION
PRODUCTS
PRODUCT OVERVIEW

ELEUTHERO EXTRACT COMPLEX [HT008]

AN MFDS-RECOGNIZED FUNCTIONAL INGREDIENT THAT MAY HELP SUPPORT JOINT HEALTH

MFDS Recognition No. 2011-28 · Collaborative Research with the Division of Rheumatology, University of Pennsylvania

A NATURAL JOINT HEALTH INGREDIENT REVIEWED THROUGH GLOBAL COLLABORATIVE RESEARCH

HT008 is a standardized botanical complex made with Eleuthero, Scutellaria baicalensis, and Angelica. Recognized by Korea’s MFDS, it may help support joint health. HT008 was evaluated in an 8-week randomized, placebo-controlled human study involving 82 adults, with a focus on joint function, inflammatory response, and safety. Supported by research with the University of Pennsylvania and publication in an international journal, HT008 is available for science-based joint health product development.

WHAT MAKES HT008 SPECIAL
FEATURES

A Natural Joint Health Ingredient Reviewed Through Global Collaborative Research

GLOBAL RESEARCH
 COLLABORATION

University of Pennsylvania
 Collaboration

HT008 was reviewed through
collaborative research
on joint-health mechanisms
with a global research institution.

8-WEEK
HUMAN STUDY

82 Adults Evaluated

Changes in pain, stiffness,
and physical function were observed
in an 8-week human study
involving 82 adults. 

COMPREHENSIVE
JOINT CARE

Cartilage Protection ·
Inflammatory Response

HT008 has been studied from a broader
joint-health perspective, including
cartilage protection, inflammatory response,
and physical function—not pain relief alone. 

No. 2011-28

No. 10-0825041

1,500mg

Eleuthero ·
Scutellaria · Angelica

mobile background
 PROBLEMS IN JOINT HEALTH
PROBLEM

Once joint damage begins, ongoing care becomes important.

Joint health concerns can involve multiple tissues, including cartilage, the synovium, ligaments, and surrounding muscles. As people age, joint discomfort can become more common, especially among older adults. Many people rely on pain relievers for temporary relief. However, pain relief alone may not fully address the underlying joint burden. A broader approach to joint health focuses not only on pain, but also on cartilage protection, inflammatory response regulation, and physical function. 

PROBLEM. 01

COMMON IN
OLDER ADULTS


Arthritis Symptoms

Joint discomfort can be associated with aging, obesity, intense physical activity, or reduced muscle strength.

PROBLEM. 02

LIMITS OF
PAIN RELIEF


Pain Control
Alone Is Not Enough

Pain relievers may provide temporary relief, but long-term joint health requires broader support.

PROBLEM. 03

ACCUMULATING
JOINT BURDEN


Repeated Stress
from Daily Movement

Everyday movements such as climbing stairs, walking, and standing up can continue to place stress on the joints.

HT008 DEVELOPMENT STORY
STORY

Joint health research began with one question
“Could joint health be supported beyond temporary symptom relief?”

2003
POTENTIAL FOUND
IN TRADITIONAL HERBS

To identify a natural product ingredient for joint health, NeuMed reviewed 300 medicinal herbs traditionally used in relation to joint health. Through cell and animal model screening, NeuMed identified the potential of a combination of Eleuthero, Scutellaria, and Angelica.


2007
MECHANISMS REVIEWED THROUGH
GLOBAL COLLABORATIVE RESEARCH

HT008’s joint-health-related mechanisms were reviewed through collaborative research with the Division of Rheumatology at the University of Pennsylvania. The research explored the potential of HT008 in relation to cartilage protection, inflammatory response regulation, and joint function from the perspective of modern joint health research. 


2011
MFDS
RECOGNITION

HT008 was evaluated for functionality and safety in a human study involving 82 adults with knee joint discomfort. It was later recognized by the MFDS for the functionality of helping support joint health. 


COMPREHENSIVE JOINT HEALTH SUPPORT
HOW IT WORKS

HT008’s Triple-Care Approach: 
Cartilage Protection, Cartilage Matrix Support, and  Inflammatory Response Regulation

As joints are used repeatedly, cartilage can experience wear and inflammatory responses may occur, making movement uncomfortable. HT008 has been studied for its potential to support joint health through three pathways: cartilage protection, cartilage matrix support, and inflammatory response regulation. 

STEP. 01

CARTILAGE PROTECTION


Inhibiting Cartilage Breakdown Signals

HT008 has been studied in relation to inflammatory cytokines associated with cartilage breakdown.

STEP. 02

CARTILAGE
MATRIX SUPPORT


Supporting Cartilage
-Related Factors

HT008 has been studied in relation to factors associated with cartilage matrix formation and joint tissue support.

STEP. 03

INFLAMMATION CONTROL


Regulating Joint
Inflammatory Mediators

HT008 has been studied in relation to inflammatory mediators involved in joint inflammatory responses.

IL-6 · TNF-α
Inhibition

Inflammatory cytokines associated
with cartilage breakdown were evaluated 


IGF-1 · BMP-2
Increase

Increase in cartilage-related factor
expression observed 


PGE₂ · PGD₂
Response           Increase

Regulation of inflammatory
mediators observed


mobile background
EVIDENCE
HUMAN
CLINICAL TRIALS

Joint-health-related indicators evaluated in adults with knee joint discomfort

An 8-week randomized, controlled human study was conducted in 82 adults with degenerative arthritis who had experienced knee joint discomfort for more than six months. In the group taking HT008 1,500 mg/day, changes were observed in joint-health-related indicators, including joint pain, stiffness, and physical function.

PAIN · FUNCTION · STIFFNESS

THREE KEY JOINT HEALTH
 INDICATORS EVALUATED


Joint Pain Improvement

VAS, which evaluates pain severity, and the WOMAC pain score, a joint pain indicator, decreased. More than 60% of participants showed improvement in both pain indicators.

Joint Function Improvement

The WOMAC function score, which evaluates joint function, and LFI, which evaluates walking and daily living function, improved. Changes were observed in daily movements such as bending the knee and going up and down stairs.

Stiffness Relief

The WOMAC stiffness score decreased. Improvement was observed in knee stiffness after waking in the morning.


COMPARED WITH GLUCOSAMINE

IMPROVEMENT IN COMPLEX JOINT HEALTH INDICATORS


Compared with the glucosamine group, the HT008 group showed greater improvement in joint-health-related indicators such as pain and walking ability. Based on the Eleuthero, Scutellaria, and Angelica complex, HT008 was evaluated for both joint-health-related functionality and safety. 

WHO IS HT008 FOR?
BENEFITS

For consumers concerned about joint discomfort and brands seeking a science-backed joint health ingredient

HT008 is an MFDS-recognized functional ingredient for joint health. Through human study data and mechanism research, HT008 has been evaluated for joint-health-related indicators, including joint pain, stiffness, and physical function.

CONSUMERS

FOR THOSE CONCERNED
 ABOUT JOINT HEALTH


Joint Health Indicator Support Within 8 Weeks

In a human study, changes were observed in joint-health-related indicators, including joint pain, stiffness, and physical function.

Support for Morning Stiffness

HT008 may help support smoother knee movement after waking, when stiffness is commonly felt.

Support for Daily Movement

By supporting joint function and walking ability, HT008 may help with daily movements such as climbing stairs and walking for longer periods.

Traditional Botanical Complex

HT008 is a natural product-based complex ingredient developed from Eleuthero, Scutellaria, and Angelica.

B2B PARTNERS AND BRANDS

FOR BRANDS SEEKING A DIFFERENTIATED JOINT HEALTH INGREDIENT


Collaborative Research with the University of Pennsylvania

HT008’s joint-health-related mechanisms were reviewed through collaborative research with the Division of Rheumatology at the University of Pennsylvania.

Three Key Joint Health Indicators Evaluated

HT008 supports a comprehensive joint care positioning by addressing pain, stiffness, and physical function together, rather than focusing on a single symptom.

Human Study and Mechanism Research Data

Human study data involving 82 adults, together with cell and animal mechanism research data, can support product planning and scientific communication.

Regionally Selected Medicinal Herbs

HT008 is developed from carefully selected medicinal herbs sourced from established production regions, supporting ingredient consistency and differentiation.

HT008 RAW MATERIALS
HT008 BOTANICAL INGREDIENTS

A Joint Health Complex Developed from Regionally Selected Medicinal Herbs

HT008 is a natural product complex ingredient developed from Eleuthero, Scutellaria, and Angelica, which have traditionally been used in relation to joint health. Raw materials are selected based on the production region and quality standards of each herb, and a combined extraction method is applied to enhance the content of key components. 

CARTILAGE SUPPORT
· INFLAMMATORY REGULATION

ELEUTHERO 


Traditional Records

Donguibogam records Eleuthero as an herb traditionally used to strengthen tendons and bones and support joint health.

Modern Research

Eleuthero has been studied in relation to IGF-1 and BMP-2 expression in chondrocytes, as well as inflammatory mediator regulation associated with cartilage health.

ANTI-INFLAMMATORY
· ANTIOXIDANT SUPPORT

SCUTELLARIA


Traditional Records

Scutellaria has traditionally been used as an herb related to heat-clearing and inflammatory response management.

Modern Research

In cell and animal models, Scutellaria has been studied in relation to NO and PGE₂ production, inflammatory response regulation, and antioxidant activity. Baicalin, a key component of Scutellaria, has also been studied for its antioxidant and anti-inflammatory properties.

BLOOD CIRCULATION
· RECOVERY SUPPORT

ANGELICA


Traditional Records

In Korean medicine, Angelica is recorded as an herb traditionally used to nourish the blood and support recovery. 

Modern Research

Ligustilide, a key component of Angelica, has been studied in relation to inflammatory cytokines such as TNF-α and IL-1β, as well as edema-related responses associated with joint discomfort.

RECOGNITION · RESEARCH · QUALITY
SCIENTIFIC RELIABILITY

HT008’s scientific reliability supported by MFDS recognition, global collaborative research, and quality management

HT008 has established its reliability as a joint health ingredient based on MFDS recognition, collaborative research with the Division of Rheumatology at the University of Pennsylvania, publication in an international journal, and a structured quality management system.

MFDS RECOGNITION 

JOINT HEALTH
FUNCTIONAL INGREDIENT


HT008 is an MFDS-recognized functional ingredient for the functionality of helping support joint health.

mobile background
INGREDIENT SUPPLY INQUIRIES
CONTACT

Start a new joint health product with HT008, a functional ingredient reviewed through global collaborative research. HT008 can be supplied as a standardized functional ingredient for brands developing differentiated joint health products. 

Based on collaborative research with the Division of Rheumatology at the University of Pennsylvania, a Korean registered patent, and quality management documentation, NeuMed supports partner brands seeking a science-backed joint health ingredient.

PRODUCT OVERVIEW

ELEUTHERO EXTRACT COMPLEX [HT008]

AN MFDS-RECOGNIZED FUNCTIONAL
INGREDIENT THAT MAY HELP SUPPORT JOINT HEALTH

MFDS Recognition No. 2011-28 · Collaborative Research
with the Division of Rheumatology, University of Pennsylvania

A NATURAL JOINT HEALTH INGREDIENT REVIEWED THROUGH GLOBAL COLLABORATIVE RESEARCH

HT008 is a standardized botanical complex made with Eleuthero, Scutellaria baicalensis, and Angelica. Recognized by Korea’s MFDS, it may help support joint health.

HT008 was evaluated in an 8-week randomized, placebo-controlled human study involving 82 adults, with a focus on joint function, inflammatory response, and safety.

Supported by research with the University of Pennsylvania and publication in an international journal, HT008 is available for science-based joint health product development.

WHAT MAKES HT008 SPECIAL
FEATURES

A Natural Joint Health Ingredient Reviewed Through Global Collaborative Research

GLOBAL RESEARCH
COLLABORATION

University of Pennsylvania
Collaboration

HT008 was reviewed through
collaborative research
on joint-health mechanisms
with a global research institution.

8-WEEK
HUMAN STUDY

82 Adults
Evaluated

Changes in pain, stiffness,
and physical function were observed
in an 8-week human study
involving 82 adults.

COMPREHENSIVE
JOINT CARE

Cartilage Protection ·
Inflammatory Response

HT008 has been studied from a broader
joint-health perspective, including
cartilage protection, inflammatory response,
and physical function—not pain relief alone.

No. 2011-28

No. 10-0825041

1,500mg

Eleuthero ·
Scutellaria · Angelica

mobile background
PROBLEMS IN JOINT HEALTH
PROBLEM

Once joint damage begins, ongoing care becomes important.

Joint health concerns can involve multiple tissues, including cartilage, the synovium, ligaments, and surrounding muscles.
As people age, joint discomfort can become more common, especially among older adults.

Many people rely on pain relievers for temporary relief.
However, pain relief alone may not fully address the underlying joint burden.
A broader approach to joint health focuses not only on pain,
but also on cartilage protection, inflammatory response regulation, and physical function.

PROBLEM. 01

COMMON IN
OLDER ADULTS


Arthritis
Symptoms

Joint discomfort can be associated
with aging, obesity, intense physical activity,
or reduced muscle strength.

PROBLEM. 02

LIMITS OF
PAIN RELIEF


Pain Control
Alone Is Not Enough

Pain relievers may provide temporary relief,
but long-term joint health requires 
broader support.

PROBLEM. 03

ACCUMULATING
JOINT BURDEN


Repeated Stress
from Daily Movement

Everyday movements such as climbing stairs,
walking, and standing up can continue
to place stress on the joints.

HT008 DEVELOPMENT STORY
STORY

Joint health research began with one question
“Could joint health be supported beyond temporary symptom relief?”

2003
POTENTIAL FOUND
IN TRADITIONAL HERBS

To identify a natural product ingredient
for joint health, NeuMed reviewed
300 medicinal herbs traditionally used
in relation to joint health. Through cell
and animal model screening, NeuMed identified
the potential of a combination
of Eleuthero, Scutellaria, and Angelica.

2007
MECHANISMS REVIEWED THROUGH
GLOBAL COLLABORATIVE RESEARCH

HT008’s joint-health-related mechanisms
were reviewed through collaborative research
with the Division of Rheumatology
at the University of Pennsylvania.
The research explored the potential of HT008
in relation to cartilage protection, inflammatory
response regulation, and joint function from
the perspective of modern joint health research. 


2011
MFDS
RECOGNITION

HT008 was evaluated for functionality
and safety in a human study involving
82 adults with knee joint discomfort.
It was later recognized by the MFDS
for the functionality
of helping support joint health.


COMPREHENSIVE JOINT HEALTH SUPPORT
HOW IT WORKS

HT008’s Triple-Care Approach
Cartilage Protection, Cartilage Matrix Support,
and Inflammatory Response Regulation

As joints are used repeatedly, cartilage can experience wear
and inflammatory responses may occur, making movement uncomfortable.

HT008 has been studied for its potential to support joint health through three pathways:
cartilage protection, cartilage matrix support, and inflammatory response regulation.

STEP. 01

CARTILAGE
PROTECTION


Inhibiting Cartilage
Breakdown Signals

HT008 has been studied in relation to inflammatory cytokines associated with cartilage breakdown.

STEP. 02

CARTILAGE
MATRIX SUPPORT


Supporting Cartilage
-Related Factors

HT008 has been studied in relation to factors associated with cartilage matrix formation and joint tissue support.

STEP. 03

INFLAMMATION
CONTROL


Regulating Joint
Inflammatory Mediators

HT008 has been studied in relation to inflammatory mediators involved in joint inflammatory responses.

IL-6 · TNF-α
Inhibition

Inflammatory cytokines associated
with cartilage breakdown were evaluated 


IGF-1 · BMP-2
Increase

Increase in cartilage-related factor
expression observed


PGE₂ · PGD₂
Response               Increase

Regulation of inflammatory
mediators observed


mobile background
EVIDENCE
HUMAN CLINICAL TRIALS

Joint-health-related indicators evaluated
in adults with knee joint discomfort

An 8-week randomized, controlled human study was conducted in 82 adults
with degenerative arthritis who had experienced knee joint discomfort for more than six months.

In the group taking HT008 1,500 mg/day, changes were observed
in joint-health-related indicators, including joint pain, stiffness, and physical function.

PAIN · FUNCTION · STIFFNESS

THREE KEY JOINT HEALTH
INDICATORS EVALUATED


Joint Pain Improvement

VAS, which evaluates pain severity,
and the WOMAC pain score, a joint pain indicator, decreased.

More than 60% of participants showed improvement in both pain indicators.

Joint Function Improvement

The WOMAC function score, which evaluates joint function, and LFI,
which evaluates walking and daily living function, improved.

Changes were observed in daily movements such as
bending the knee and going up and down stairs.

Stiffness Relief

The WOMAC stiffness score decreased.

Improvement was observed in knee stiffness after waking in the morning.

COMPARED WITH GLUCOSAMINE

IMPROVEMENT
IN COMPLEX JOINT
HEALTH INDICATORS


Compared with the glucosamine group, the HT008 group showed greater improvement in joint-health-related indicators such as pain and walking ability. Based on the Eleuthero, Scutellaria, and Angelica complex, HT008 was evaluated for both joint-health-related functionality and safety. 

WHO IS HT008 FOR?
BENEFITS

For consumers concerned about joint discomfort
and brands seeking a science-backed joint health ingredient

HT008 is an MFDS-recognized functional ingredient for joint health.
Through human study data and mechanism research, HT008 has been evaluated
for joint-health-related indicators, including joint pain, stiffness, and physical function.

CONSUMERS

FOR THOSE CONCERNED
ABOUT JOINT HEALTH

Joint Health Indicator Support
Within 8 Weeks

In a human study, changes were observed in joint-health-related
indicators, including joint pain, stiffness, and physical function.

Support for Morning Stiffness

HT008 may help support smoother
knee movement after waking,
when stiffness is commonly felt.

Support for Daily Movement

By supporting joint function and walking ability,
HT008 may help with daily movements such as
climbing stairs and walking for longer periods.

Traditional Botanical Complex

HT008 is a natural product-based complex ingredient developed
from Eleuthero, Scutellaria, and Angelica.

B2B PARTNERS AND BRANDS

FOR BRANDS SEEKING A DIFFERENTIATED
JOINT HEALTH INGREDIENT

Collaborative Research
with the University of Pennsylvania

HT008’s joint-health-related mechanisms were reviewed through collaborative
research with the Division of Rheumatology at the University of Pennsylvania.

Three Key Joint Health Indicators Evaluated

HT008 supports a comprehensive joint care positioning
by addressing pain, stiffness, and physical function together,
rather than focusing on a single symptom.

Human Study and Mechanism Research Data

Human study data involving 82 adults, together with cell
and animal mechanism research data, can support product planning
and scientific communication.

Regionally Selected Medicinal Herbs

HT008 is developed from carefully selected medicinal herbs sourced
from established production regions, supporting ingredient consistency
and differentiation.

HT008 RAW MATERIALS
HT008 BOTANICAL INGREDIENTS

A Joint Health Complex Developed from Regionally Selected Medicinal Herbs

HT008 is a natural product complex ingredient developed from Eleuthero, Scutellaria,
and Angelica, which have traditionally been used in relation to joint health.

Raw materials are selected based on the production region and quality standards of each herb,
and a combined extraction method is applied to enhance the content of key components.

CARTILAGE SUPPORT · INFLAMMATORY REGULATION

ELEUTHERO


Traditional Records

Donguibogam records Eleuthero as an herb traditionally
used to strengthen tendons and bones and support joint health.

Modern Research

Eleuthero has been studied in relation to IGF-1 and BMP-2 expression
in chondrocytes, as well as inflammatory mediator regulation associated with cartilage health.

ANTI-INFLAMMATORY · ANTIOXIDANT SUPPORT

SCUTELLARIA


Traditional Records

Scutellaria has traditionally been used as an herb related
to heat-clearing and inflammatory response management.

Modern Research

In cell and animal models, Scutellaria has been studied in relation to NO and PGE₂ production,
inflammatory response regulation, and antioxidant activity. Baicalin, a key component of Scutellaria,
has also been studied for its antioxidant and anti-inflammatory properties.

BLOOD CIRCULATION · RECOVERY SUPPORT

ANGELICA


Traditional Records

In Korean medicine, Angelica is recorded as an herb traditionally
used to nourish the blood and support recovery.

Modern Research

Ligustilide, a key component of Angelica, has been studied in relation to inflammatory
cytokines such as TNF-α and IL-1β, as well as edema-related responses associated with joint discomfort.

RECOGNITION · RESEARCH · QUALITY
SCIENTIFIC RELIABILITY

HT008’s scientific reliability supported by MFDS recognition,
global collaborative research, and quality management

HT008 has established its reliability as a joint health ingredient based on MFDS recognition, collaborative research with the Division of Rheumatology at the University of Pennsylvania, publication in an international journal, and a structured quality management system.

MFDS RECOGNITION 

JOINT HEALTH
FUNCTIONAL INGREDIENT


HT008 is an MFDS-recognized
functional ingredient
for the functionality of helping
support joint health.

GLOBAL RESEARCH COLLABORATION

UNIVERSITY OF
PENNSYLVANIA


HT008 was studied with the University
of Pennsylvania’s Division of Rheumatology,
and the results were published
in an international journal.

QUALITY MANAGEMENT SYSTEM

THREE-STEP
QUALITY TESTING


NeuMed manages the quality, purity, and stability
of Eleuthero, Scutellaria, and Angelica through
manufacturer analysis, NeuMed in-house analysis,
and third-party accredited laboratory analysis.

mobile background
INGREDIENT SUPPLY INQUIRIES
CONTACT

Start a new joint health product with HT008, a functional ingredient reviewed through global collaborative research. HT008 can be supplied as a standardized functional ingredient for brands developing differentiated joint health products. 

Based on collaborative research with the Division of Rheumatology at the University
of Pennsylvania, a Korean registered patent, and quality management documentation,
NeuMed supports partner brands seeking a science-backed joint health ingredient.

COMPANY : NEUMED, Inc / CEO : Hocheol Kim 
TEL : +82-2-564-9140 / FAX : +82-2-564-9290
MAIL : sales@neumed.co.kr / BUSINESS LICENSE : 204-81-77134
ADD : 6F, 88 Imun-ro, Dongdaemun-gu, Seoul, Republic of Korea

4F, Seongsu SK V1 CENTER I, 48 Achasan-ro 17-gil, Seongdong-gu, Seoul, Republic of Korea

ⓒ 2026 NEUMED. ALL RIGHTS RESERVED.

COMPANY : NEUMED, Inc / CEO : Hocheol Kim 
TEL : +82-2-564-9140 / FAX : +82-2-564-9290
MAIL : sales@neumed.co.kr
BUSINESS LICENSE : 204-81-77134
ADD : 6F, 88 Imun-ro, Dongdaemun-gu,
Seoul, Republic of Korea

4F, Seongsu SK V1 CENTER I, 48 Achasan-ro
17-gil, Seongdong-gu, Seoul, Republic of Korea 

ⓒ 2026 NEUMED. ALL RIGHTS RESERVED.